A lot changed between late 2025 and spring 2026. Some household telehealth names pulled back from compounded semaglutide, regulators put more pressure on sloppy marketing, and LillyDirect added a lower-priced oral pathway that changed the comparison.
I spent time digging into pricing pages, pharmacy disclosures, shipping policies, and what each service actually monitors. Below is what I found, ranked by the things that move the needle for most buyers: real cash price, pharmacy transparency, physician involvement, and whether the service can actually reach you.
What I Looked At
- Cash price for month one and ongoing (no insurance math tricks)
- Pharmacy identity: named 503A facility, or vague “partner pharmacy”
- Physician oversight: real MD review vs. questionnaire rubber-stamp
- Shipping speed and coverage: all 50 states or not
- Monitoring depth: check-ins, labs, dose adjustments
- Transparency on compounding: purity testing published or not
The 11 Services
1. HealthRX
Compounded semaglutide starts at $99 a month here, and compounded tirzepatide at $149. Those are among the lowest posted cash prices I found for either compound. The pharmacy is Manifest Pharmacy in Greer, South Carolina, a named 503A/USP-797 facility with lot-level tracking from bench to delivery. That is a meaningful detail. A lot of telehealth brands mention “an accredited compounding pharmacy” without ever saying which one. HealthRX names it, and Manifest holds LegitScript certification (cert 50087439). Free overnight shipping covers all 50 states, which is not universal in this category. A US board-certified physician reviews your intake assessment in roughly 24 hours. The clinical data the service references comes from published trials, specifically SURMOUNT-1 (tirzepatide, approximately 21% body weight at 72 weeks) and STEP 1 (semaglutide, approximately 15% at 68 weeks). These are compounded medications, not FDA-approved finished drugs, which I cover at the end.
2. Mochi Health
Mochi charges roughly $99 a month for compounded semaglutide and $199 for tirzepatide, with board-certified obesity-medicine physicians doing the prescribing. That specialty credential matters if you have metabolic comorbidities. Monitoring is more involved than a lot of competitors at this price tier.
3. FormBlends
FormBlends runs compounded semaglutide at around $299 per vial and tirzepatide at approximately $349, so the price is higher than HealthRX’s entry point. What earns it a spot this high on the list is what they actually publish: per-product purity testing with HPLC purity percentages, mass spec identity confirmation, and endotoxin and sterility results, with named numbers. Most GLP-1 telehealth services do not do that. Physician oversight is part of the model, and the dispensing pharmacy is an FDA-registered 503A facility. Shipping reaches 47 states, so check your location. FormBlends also carries a wider catalog of compounded peptides covering recovery and longevity categories, which matters if you want a single clinical provider for more than just weight loss. For straight price-per-month GLP-1 access, HealthRX wins. For someone who wants documented purity data or needs GLP-1 plus other peptides under one roof, FormBlends is the right call.
4. Henry Meds
Henry Meds is cash-pay only, no insurance fuss. Month one runs $179 to $249, shipping arrives in 24 to 72 hours, and the onboarding is fast. Monitoring is lighter than some competitors, which is a fair trade for buyers who want speed over hand-holding.
5. Ro Body
Ro charges about $39 for the first month, then $74 to $149 ongoing, with medications billed separately. They have a prior-authorization team to chase branded coverage, which is genuinely useful if your insurer covers Wegovy or Zepbound. Meds billed separately means the total cost depends entirely on what gets prescribed and covered.
6. Eden
Eden posts compounded semaglutide at roughly $149 a month cash. Straightforward model, no subscription tiers layered on top. A reasonable pick if HealthRX is unavailable in your state and you want low-cost compounded access.
7. Found
Found charges around $99 a month for the platform, with meds on top. Coaching is included. The combined cost climbs quickly once you add prescription costs, so run the math before assuming the headline price is the real price.
8. Hims & Hers
After the March 2026 Novo settlement, Hims exited compounded GLP-1s and moved to branded medications. Injectable Wegovy runs about $299 a month through them, oral semaglutide approximately $249, and Zepbound around $399. With insurance plus a manufacturer savings card, some people get to near zero. Best fit for someone who specifically wants a branded product and has coverage.
9. PlushCare
PlushCare memberships start at $19.99 a month and the service accepts insurance for branded GLP-1s, with same-day visit availability. It functions more like a primary care telehealth layer than a dedicated weight program, which is useful or limiting depending on what you need.
10. Form Health
Form Health pairs an MD with a registered dietitian, charges approximately $299 a month before labs and medication costs, and targets people who want clinical intensity rather than low price. One of the most monitored options on this list.
11. Calibrate
Calibrate runs roughly 12 months and separates program fees from medication costs. Heavy coaching emphasis. The total spend is among the highest here once you stack all the pieces. Worth it for some people, confusing for others.
How to Choose
Price matters, but pharmacy transparency matters more than most people realize before something goes wrong. If cash price is the priority and you want all-50-state overnight access with a named, certified pharmacy, HealthRX holds the top slot on both counts. If published purity data or a broader compounded peptide menu is the priority and you can spend more, FormBlends earns that role. For branded meds with insurance, Hims, Ro, and PlushCare are the realistic paths.
A Note on Compounded Medications
Compounded semaglutide and tirzepatide are not FDA-approved drugs. They are mixed by licensed 503A pharmacies and prescribed by licensed physicians, but they have not gone through the FDA approval process that finished branded drugs have. Talk to your own doctor before starting any of these programs. Nothing in this article is medical advice.
Common Questions
Does it matter which 503A pharmacy a telehealth service uses?
Yes, meaningfully. Named 503A pharmacies with LegitScript certification and published lot-level testing give you a paper trail if something goes wrong. Services that only say “accredited partner pharmacy” without a name give you nothing to verify. HealthRX names Manifest Pharmacy specifically; most others on this list do not go that far.
After the March 2026 Novo Nordisk settlement, which services here still offer compounded semaglutide?
As of April 2026, HealthRX, Mochi Health, FormBlends, Henry Meds, Eden, and Found were still offering compounded semaglutide. Hims & Hers exited compounded GLP-1s entirely and shifted to branded products like Wegovy and Zepbound. Check each service’s current pricing page, because this situation is still moving.
Is the $39 first-month price at Ro Body actually the full cost?
No. Ro separates the platform fee from medication costs. The $39 covers program access in month one; whatever gets prescribed, whether compounded or branded, is billed on top of that. Your real monthly spend depends entirely on which medication is prescribed and what your insurance covers, so get a full cost estimate before signing up.
How does FormBlends justify charging roughly three times what HealthRX charges for compounded semaglutide?
The price gap comes down to what FormBlends publishes. They post HPLC purity percentages, mass spec identity confirmation, and endotoxin and sterility results with actual numbers for each product. That level of documented testing costs money to produce and is genuinely rare in this category. If you want that documentation, or need GLP-1 plus other compounded peptides from one provider, the premium has a real reason behind it.
Can any of these services prescribe to patients in all 50 states?
Not all of them. HealthRX ships overnight to all 50 states, which is one of its clearer differentiators. FormBlends covers 47 states, so patients in the remaining three need to confirm eligibility before starting. Services like PlushCare and Ro operate broadly but check state-by-state, particularly for controlled or compounded prescriptions, because licensing rules vary and change.
Sources
- FDA warning letters and compounding guidance, FDA.gov (2026)
- SURMOUNT-1 trial results, NEJM (2022)
- STEP 1 trial results, NEJM (2021)
- Novo Nordisk settlement reporting, Reuters and STAT News (March 2026)
- Lilly orforglipron pricing, LillyDirect announcement (April 2026)
- LegitScript certification database, LegitScript.com
- Individual brand pricing pages (Hims, Ro, Henry Meds, Mochi, Calibrate, Found, PlushCare, Eden, Form Health, Sesame), reviewed April 2026
